PhD Student (m/f/d)

"Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 7,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative departments. The close connection of health care with research and teaching, as well as a climate of collegiality, internationality, and cross-professional cooperation characterize the university hospital.

PhD Student Position in Lymphoma Research (m/f/d)

(We are targeting applicants of all genders)

Full time | initially limited to 3 yeasrs | Announcement number: 519-2024

The Department of Hematology and Oncology at the Goethe University Hospital Frankfurt offers the full spectrum of blood and cancer diagnostics and therapy. The research group of Dr. Sebastian Scheich is part of the Frankfurt Cancer Institute (FCI, https://fci.health) and focuses on aggressive lymphoma biology and signaling. The lab is furthermore funded by grants from “Else Kröner-Fresenius-Stiftung”, "Deutsche Krebshilfe" and "BMBF" and is embedded in a vibrant research environment within the FCI and maintains lively international collaborations. We apply cutting-edge technologies including genome-wide CRISPR/Cas9 screens, quantitative functional proteomics and super resolution microscopy (dSTORM, single molecule tracking, SIM) to dissect oncogenic signaling pathways, study therapy resistance mechanisms and to find novel therapeutic vulnerabilities. We are looking for a highly motivated PhD student to join our team.

The current research projects are based on a recent publication identifying N-linked glycosylation as a therapeutic target for the treatment of aggressive lymphomas (Scheich et al., Cancer Disc May 4:CD-22-1401; Phelan and Scheich et al. Cancer Cell. 2024 Feb 12;42(2):238-252.e9).

Your project will be a follow-up based on preliminary data to mechanistically dissect oncogenic signaling pathways in lymphoma models

Conduction of genome scale CRISPR/Cas9 screens and functional proteomic experiments including posttranslational modification profiling

Utilization of cutting-edge imaging modalities including dSTORM, single molecule tracking, structured illumination microscopy (SIM) and proximity ligation assays

Independent planning, execution and analysis of experiments in the field of lymphoma research

Application of standard molecular biology and biochemistry methods (tissue culture, flow cytometry, western blotting)

Master degree or equivalent in molecular medicine, biology, biochemistry or related fields

Solid hands-on research experience in basic cell biology, biochemistry and molecular biology methods

Fascination and motivation for biomedical research in the field of cancer biology

Enthusiasm to learn and implement novel technologies

High motivation for experimental lab work, analysis of “omics” data and data presentation

Ability to work in a team, sense of responsibility and proactivity

Basic knowledge in MS office (Word, Excel)

Fluent English

Due to legal regulations, valid proof of measles immunity / measles vaccination is required

Collective agreement: Salary based on German scale TV-L 13 65 % with additional benefits benefit from long-term security through company pension schemes

Mobility: Free public transport in all Hessen (Free State Ticket Hessen)

Campus: Our attractive university hospital campus offers a modern cafeteria, various cafes, and opportunities to rest in numerous green spaces. A walk on the riverside of the Main offers relaxation during breaks

Work-Life-Balance: Part-time employment is possible, we offer childcare in our daycare center (if you have any questions, please contact apply.job.21716864@hokifyjob.com child care during holidays

Health Promotion: Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrit...