Computational Biologist (m/f/d)

LIQOMICS GmbH is a Cologne-based biotech company specializing in the diagnostics of circulating tumor DNA in blood samples (liquid biopsy). Our diagnostics support physicians as well as cancer patients worldwide in making the right decisions before, during, and after therapy.

Our mission: Through our innovative diagnostics, we want to reduce the number of preventable cancer-related deaths to zero.

To strengthen our team, we are looking for a Computational Biologist with hands-on experience in next-generation sequencing data analysis. This role is for someone who thrives on understanding genomic data, building analytical methods, and extracting meaningful biological signals from sequencing data.

TASKS

• Design, build, and optimize bioinformatics pipelines for cfDNA analysis
• Investigate sources of noise, bias, and technical artifact in NGS data and design computational strategies to address them
• Perform deep exploratory data analysis on large-scale sequencing datasets to generate and test biological hypotheses
• Build statistical and machine learning models to detect low-allele-fraction somatic variants, tumor-derived signal, and other cfDNA-specific features
• Collaborate with wet-lab scientists to translate biological questions into computational experiments and interpret results in a clinically meaningful context

REQUIREMENTS

• A relevant university degree or equivalent experience
• Proficiency in Python for data analysis, statistical modeling, and pipeline development
• Hands-on experience analyzing large amounts of genomic data, preferably with direct exposure to cfDNA and liquid biopsy
• Understanding of the technical challenges specific to NGS and cfDNA: low allele fractions, fragment-level features, and noise modeling
• Experience building statistical or machine learning models

Cover Letter (required)

Please keep it to one page. In our organization individual contributions are highly visible, so concrete examples of what you personally have done help more than general statements.

1. Why this role: Why does this work appeal to you, and what are you looking for next? Feel free to include your ideal work environment or anything else that helps us get to know you.

2. What you have built: Tell us about a pipeline or analysis you are proud of (for example, NGS, variant calling, noise modeling). What made it demanding, what specifically was your contribution, and was it used in research, production, or the clinic?

3. A project you are proud of: Describe a project where you did your best work. What was your role, what did it lead to, and what would you push further next time?

BENEFITS

A friendly, dynamic team with diverse professional backgrounds, true team spirit, and a mission that matters. At LIQOMICS, you actively shape your area and see directly what your work achieves. You have a wide range of development opportunities and can actively shape your professional path with us.